DRG Salivary Estriol Free, 96 Wells
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Manufacturer: DRG International Inc.
Model: Salivary Estriol Free, 96 Wells
Product Code: SLV-3653
The Salivary Estriol Free, 96 Wells from DRG International Inc. is an enzyme immunoassay for measurement of free estriol in saliva. You can purchase this product easily and conveniently from Block Scientific, a leading laboratory equipment supplier, by way of our online store.
Estriol (also Oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the fetus. During pregnancy the production of estriol depends on an intact maternal-placental-fetal unit. Fetal-placental production of estriol leads to a progressive rise in maternal circulating levels reaching a late-gestational peak several orders of magnitude greater than non-pregnant levels. In the maternal circulation, estriol undergoes a rapid conjugation in the liver followed by urinary excretion with a half-life of about 20 minutes. Since normal estriol production depends on an intact maternal-placental-fetal circulation and functional fetal metabolism, maternal estriol levels have been used to monitor fetal status during pregnancy, particularly during the third trimester. DHEA-S is produced by the adrenal cortex of the fetus, this is converted to estriol by the placenta. If levels are abnormally low in a pregnant woman, this may indicate a problem with the development in the child. Levels of estriol in non-pregnant women do not change much after menopause, and levels are not significantly different from levels in men.
DRG Salivary Free Estriol ELISA Kit
– Principle of the Test
The DRG Salivary Free Estriol ELISA Kit is a solid phase enzyme-linked immunosorbent assay (ELISA), based on the principle of competitive binding. The microtiter wells are coated with an anti-Estriol IgG antibody. Endogenous unconjugated (“free”) Estriol of a sample competes with an Estriol-horseradish peroxidase conjugate for binding to the coated antibody. After incubation the unbound conjugate is washed off. The amount of bound peroxidase conjugate is inversely proportional to the concentration of Estriol in the sample. After addition of the substrate solution, the intensity of colour developed is inversely proportional to the concentration of free Estriol in the sample.
If you have any questions about the DRG Salivary Estriol Free, 96 Wells or other hormone assays in saliva , dial 631-589-1118 and speak to one of our customer service representatives.