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drg salivary 17-oh-progesterone, 96 wells

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drg salivary 17-oh-progesterone, 96 wells
  1. drg international inc.
  2. slv-3140

block scientific, the leading laboratory equipment supplier offers the salivary 17-oh-progesterone, 96 wells, just one of the many elisa kits and antibodies that we make available to an extensive clientele. we deal in brand new as well as refurbished lab equipment.

applications of

salivary 17-oh-progesterone

it is a immunoenzymatic calorimetric technique to find out the quantitative in-vitro measurement of active free 17 α oh progesterone in saliva.

summary and features

the steroid 17-α-hydroxyprogesterone (17-α-ohp) is produced by both the adrenal cortex and gonads. even though 17-α-ohp has relatively little progestational activity, it is of intense clinical interest because it is the immediate precursor to 11-desoxycortisol (cpd-s). because cpd-s is produced by 21-hydroxylation of 17-α-ohp, measurement of 17α-ohp is a useful indirect indicator of 21-hydroxylase activity.

in congenital 21-hydroxylase deficiency, the most common variety of congenital adrenal hyperplasia (cah), 17-α-ohp is secreted in abundant excess. it is moderately elevated in the 11-β-hydroxylase deficiency as well. measurement of 17-α-ohp is therefore valuable in the initial diagnosis of cah.

adult non-pregnant women:

in adult non-pregnant women in the childbearing age group, 17-α-ohp concentrations vary over the menstrual cycle with luteal phase concentrations being higher than follicular phase concentrations. this is because 17-α-ohp is secreted parallel with progesterone from maturing follicles or from the corpus luteum. there is also a diurnal variation of 17-α-ohp concentrations.

this rhythm is parallel with adrenal cortisol secretion such that maximum 17-α-ohp concentrations are measured in samples obtained in the morning.

congenital adrenal hyperplasia:

the principal application of the 17-α-ohp is in the diagnosis of cah in newborns with ambiguous genitalia and in virilized adolescent girls. since 17-α-ohp is the immediate precursor to 11-desoxycortisol, basal 17-α-ohp concentrations are sharply elevated in patients with 21-hydroxylase deficiency and to a lesser degree in patients with 11-hydroxylase deficiency. because 17-α-ohp concentrations are so markedly elevated in newborns and adolescent girls afflicted with cah, a single basal measurement is all that is normally required to make the diagnosis.

late onset adrenal hyperplasia:

more recently, 17-α-ohp concentrations have been utilized in the evaluation of androgenized women where late onset 21-hydroxylase is suspected. this condition is clinically very subtle and since the presentation is the same as classical polycystic ovarian disease, basal plasma 17-α-ohp concentrations, unlike classical congenital adrenal hyperplasia, are normal. the diagnosis is made by administration of an acth stimulation test.

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