drg salivary 17-oh-progesterone, 96 wells
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- drg international inc.
block scientific, the leading laboratory equipment supplier offers the salivary 17-oh-progesterone, 96 wells, just one of the many elisa kits and antibodies that we make available to an extensive clientele. we deal in brand new as well as refurbished lab equipment.
it is a immunoenzymatic calorimetric technique to find out the quantitative in-vitro measurement of active free 17 α oh progesterone in saliva.
summary and features
the steroid 17-α-hydroxyprogesterone (17-α-ohp) is produced by both the adrenal cortex and gonads. even though 17-α-ohp has relatively little progestational activity, it is of intense clinical interest because it is the immediate precursor to 11-desoxycortisol (cpd-s). because cpd-s is produced by 21-hydroxylation of 17-α-ohp, measurement of 17α-ohp is a useful indirect indicator of 21-hydroxylase activity.
in congenital 21-hydroxylase deficiency, the most common variety of congenital adrenal hyperplasia (cah), 17-α-ohp is secreted in abundant excess. it is moderately elevated in the 11-β-hydroxylase deficiency as well. measurement of 17-α-ohp is therefore valuable in the initial diagnosis of cah.
adult non-pregnant women:
in adult non-pregnant women in the childbearing age group, 17-α-ohp concentrations vary over the menstrual cycle with luteal phase concentrations being higher than follicular phase concentrations. this is because 17-α-ohp is secreted parallel with progesterone from maturing follicles or from the corpus luteum. there is also a diurnal variation of 17-α-ohp concentrations.
this rhythm is parallel with adrenal cortisol secretion such that maximum 17-α-ohp concentrations are measured in samples obtained in the morning.
congenital adrenal hyperplasia:
the principal application of the 17-α-ohp is in the diagnosis of cah in newborns with ambiguous genitalia and in virilized adolescent girls. since 17-α-ohp is the immediate precursor to 11-desoxycortisol, basal 17-α-ohp concentrations are sharply elevated in patients with 21-hydroxylase deficiency and to a lesser degree in patients with 11-hydroxylase deficiency. because 17-α-ohp concentrations are so markedly elevated in newborns and adolescent girls afflicted with cah, a single basal measurement is all that is normally required to make the diagnosis.
late onset adrenal hyperplasia:
more recently, 17-α-ohp concentrations have been utilized in the evaluation of androgenized women where late onset 21-hydroxylase is suspected. this condition is clinically very subtle and since the presentation is the same as classical polycystic ovarian disease, basal plasma 17-α-ohp concentrations, unlike classical congenital adrenal hyperplasia, are normal. the diagnosis is made by administration of an acth stimulation test.
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