The discovery and development of green fluorescent protein or GFP was recognized in 2008. GPF opened new doors for studying cell biology. The GPF gene is attached to the protein under study so that when the protein is made, it will have GPF attached to it. The fluorescently labeled protein is easily detectable under a fluorescence microscope. However, GPF has the limitation that it cannot be used with electron microscopy.
A recent report in MIT News says that its researchers have come up with a new GPF parallel for electron microscopy. Termed APEX, this new tag is expected to allow scientists to label and view proteins with exceptional clarity using electron microscopy. It can help them identify the location of several cell protein functions and study their functions.
This discovery is a great breakthrough for electron microscopy which allows the visualization of cell structures that are not normally visible using optical microscopy.
Both electron and fluorescence microscopes have their unique uses and leading lab equipment dealers stock both categories in their inventory. Block Scientific offers high quality, new and recertified electron and fluorescence microscopes from leading names such as UNICO and LW Scientific.
A popular model, the new UNICO G380 Series with LED illumination is specifically designed to reduce eyestrain for users wearing glasses. Each eye tube features independent focusing diopter adjustment to compensate for the natural vision differential between each eye. The base design adds stability to the body and also allows easy operation of the controls. UNICO’s Binocular Microscope comes with 100XR-fluorescence objectives and is a highly durable and reliable model. The Bend-E 5x/10x Fluorescent Ring Light Stereoscope from LW Scientific is both ergonomic and efficient. It offers long working distances, high resolution optics, and deep field depths.